Folate Receptor Antibodies In Mental Health

There is significant evidence that folate receptor autoantibodies (FRAAs) can interfere with the uptake of folate, potentially leading to conditions of cerebral folate deficiency, which is associated with various neurological disorders. The presence of these autoantibodies is more prevalent in specific conditions, such as autism spectrum disorders and other neurodevelopmental disorders​. As clinicians, we can easily incorporate testing for the FRAAs, along with appropriate treatment to address the central nervous system folate deficiencies that may be a causal factor for many mental health conditions including autism spectrum disorder, treatment-resistant depression, schizophrenia, PANS/PANDAS and bipolar disorder.