Practitioner Course

Mast Cell Activation Syndrome with Dr Theoharides

What do mast cells have to do with pain, fatigue, allergies and even autism? Explore this topic with world expert Dr Theoharides.

Online Course
1 lesson


12 Months OR Subscriber Pass


1 lesson
1 hour total


Dr Theoharis Theoharides

About this course

The increase in allergies, asthma, eczema, rhinitis, and food sensitivities that we are seeing is not readily explainable. Also, there are numerous cases of patients presenting with symptoms consistent with atopic disorders but without a recognisable allergic trigger, or with non-allergic triggers. It appears that this changing picture is due to the rapidly growing population of people presenting with Mast Call Activation Syndrome (MCAS).

Patients with MCAS have normal numbers of mast cells but abnormal function of these cells. They may be degranulating independent of the usual triggers, or releasing excessive amounts of inflammatory compounds. Mast cells are found in connective tissues, skin, intestine lining, cardiovascular system, reproductive system, and neural system. They are relatively small and have a cell life span of only up to 12 weeks. When activated mast cells release various chemicals into the blood stream including histamine, serotonin, heparin, chondroitin sulfate, tryptase, chymase, interleukin-4, and TNF-α. 

Those people with Mast Cell Activation Syndrome are highly reactive individuals and the high levels of histamine that they are exposed to results in itchy skin, flushing, nasal congestion, headache, nausea, gastric hypersecretion, and wheezing. Because mast cells are so wide-spread there is a long list of conditions that have mast cell involvement. For example, mast cells can disrupt the blood-brain barrier. When toxins enter the brain, the mast cells can become activated causing localised inflammation to certain areas in the brain and also permitting more toxins to enter the brain.

Dr Theoharis Theoharides is an expert in mast cell pathology and has researched and presented extensively on the topic. He was the first to show that mast cells are critical for inflammation, especially in the brain, and that they are involved in a number of inflammatory conditions that worsen with stress, such as allergies, asthma, eczema, psoriasis, migraines, multiple sclerosis and most recently autism spectrum disorder. In this presentation, Theoharis give us new and deep understanding of mast cells and therefore immune system.

A critical aspect of this presentation is that there is a very long list of conditions that mimic MCAS that are not recognised as being mast cell mediated. Recognising mast cell dysfunction as a potential cause of these conditions makes enormous differences to these patients ability to recover and become well. Theoharis dives deep into these conditions and gives you some good tools and strategies to help these patients.
What you receive:
  • Clear protocol explanations from some of the world's top practitioners
  • Clinical pearls for improved practice results
  • Access to your audio and video recordings via the App Store
  • A downloadable PDF of the presenter’s slides
  • Links to all referenced research papers and useful clinical handouts
  • Access to the community hub where you can get answers to your questions
  • A 30-day money back guarantee

From this course you will

  • Learn the fascinating physiology of mast cells and their range of effects
  • See which conditions mimic and are often confused for MCAS
  • Be amazed at the breadth of systems and conditions affected by mast cell dysfunction
  • Learn the unique characteristics of MCAS

What's in this course

Your Presenter

Theoharis C. Theoharides, BA, MS, MPhil, PhD, MD, FAAAAI

Dr Theoharides is Professor of Pharmacology and Internal Medicine, as well as Director of Molecular Immunopharmacology and Drug Discovery, in the Department of Immunology at Tufts University School of Medicine, Boston, MA, USA. He is also Adjunct Professor at the Institute of Neuro-Immune Medicine, Nova Southeastern University, Tampa, FL, USA, as well as Director of Health Science Programs and Research, American College of Greece, Athens, Greece.

He was born in Thessaloniki, Greece, and graduated with Honors from Anatolia College. He received all his degrees from Yale University (BA, cum laude in Biology and History of Medicine, MS, MPhil, PhD, MD), and was awarded the Dean’s Research Award and the Winternitz Price in Pathology. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award “recognising excellence, compassion and service.” He also received a Certificate in Global Leadership from the Tufts Fletcher School of Law and Diplomacy and a Fellowship at the Harvard Kennedy School of Government. He has been serving as the Clinical Pharmacologist of the Massachusetts Drug Formulary Commission continuously since 1986.

In Greece, he served on the Supreme Advisory Health Councils of the Ministries of Health and of Social Welfare, as well as on the Board of Directors of the Institute of Pharmaceutical Research and Technology. He Chaired an International Committee appointed by the Hellenic Ministries of Education and Health for the establishment of an independent medical school in Greece, and he is a member of the International Advisory Committee for the University of Cyprus School of Medicine. He is also the Director of Health Science Programs and Research for the American College of Greece. He is a member of 15 academies and scientific societies. He was inducted into the Alpha Omega Alpha National Medical Honour Society and the Rare Diseases Hall of Fame. He has received the Tufts Excellence in Teaching ten times, the Tufts Distinguished Faculty Recognition Award twice, the Tufts Alumni Award for Faculty Excellence, and the Dr. George Papanicolaou Award.

He has also been awarded an Honorary Doctor of Medicine from Athens University and an Honorary Doctor of Sciences from Hellenic-American University, as well as the 2018 Albert Nelson Marquis Lifetime Achievement Award. Dr Theoharides is a member of the American Academy of Allergy, Asthma and Immunology. In 2020, he was inducted in the World Academy of Sciences. For his humanitarian efforts, he was honoured with Boston Mayor’s Community Award, the 2018 Distinguished Humanitarian Award (Marquis Who is Who), and he was recognised as “Archon” of the Ecumenical Patriarchate of Constantinople.

Dr Theoharides first showed that mast cells, known for causing allergic reactions, are critical for inflammation, especially in the brain, and are involved in a number of conditions that worsen with environmental triggers, especially mould, and stress such as allergies, asthma, autism spectrum disorder, eczema, fibromyalgia, interstitial cystitis/bladder pain syndrome, mast cell activation syndrome, migraines, multiple sclerosis, myalgic encephalomyelitis/ chronic fatigue syndrome, psoriasis and Long-COVID syndrome.

He has published over 480 scientific papers (in journals such as JBC, JACI, JPET, NEJM, Nature, PNAS, Science) with 40,276 citations (h-index 96) and 3 textbooks of pharmacology. He has been placed in the top 5% of authors most cited in pharmacological and immunological journals. He was instrumental in the development of ibuprofen (Motrin, with Upjohn), cetirizine (Zyrtec, with UCB) and slow-release niacin (Niaspan, with Abbott).